General Information

  • ID:  hor000310
  • Uniprot ID:  NA
  • Protein name:  [HYP3]Met-callatostatin
  • Gene name:  NA
  • Organism:  Calliphora vomitoria
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  midgut
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GPXYDFGM
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T8 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It show allatostatic activity by inhibiting juvenile hormone synthesis and release;inhibits the peristaltic movements of the hindgut
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: allatostatic activity:100 pM;peristaltic movements:0.5 pM and 0.5 mM
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000310_AF2.pdbhor000310_ESM.pdb

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Physical Information

Mass: 100289 Formula: C36H45N7O10S
Absent amino acids: ACEHIKLNQRSTVW Common amino acids: G
pI: 3.75 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 1
Hydrophobicity: -31.25 Boman Index: -165
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 2642.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  8063725
  • Title:  [Hyp3]Met-callatostatin. Identification and Biological Properties of a Novel Neuropeptide From the Blowfly Calliphora Vomitoria